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Titel:

Effects of Empagliflozin on Fluid Overload, Weight, and Blood Pressure in CKD.

Dokumenttyp:
Article; Randomized Controlled Trial; Journal Article
Autor(en):
Mayne, Kaitlin J; Staplin, Natalie; Keane, David F; Wanner, Christoph; Brenner, Susanne; Cejka, Vladimir; Stegbauer, Johannes; Judge, Parminder K; Preiss, David; Emberson, Jonathan; Trinca, Daniele; Dayanandan, Rejive; Lee, Ryonfa; Nolan, John; Omata, Akiko; Green, Jennifer B; Cherney, David Z I; Hooi, Lai Seong; Pontremoli, Roberto; Tuttle, Katherine R; Lees, Jennifer S; Mark, Patrick B; Davies, Simon J; Hauske, Sibylle J; Steubl, Dominik; Brückmann, Martina; Landray, Martin J; Baigent, Colin;...     »
Abstract:
SIGNIFICANCE STATEMENT: SGLT2 inhibitors reduce risk of kidney progression, AKI, and cardiovascular disease, but the mechanisms of benefit are incompletely understood. Bioimpedance spectroscopy can estimate body water and fat mass. One quarter of the EMPA-KIDNEY bioimpedance substudy CKD population had clinically significant levels of bioimpedance-derived "Fluid Overload" at recruitment. Empagliflozin induced a prompt and sustained reduction in "Fluid Overload," irrespective of sex, diabetes, an...     »
Zeitschriftentitel:
J Am Soc Nephrol
Jahr:
2024
Band / Volume:
35
Heft / Issue:
2
Seitenangaben Beitrag:
202-215
Volltext / DOI:
doi:10.1681/ASN.0000000000000271
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38082486
Print-ISSN:
1046-6673
TUM Einrichtung:
1121; Professur für Nephrologie (Prof. Heemann)
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