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Titel:

A Novel Approach for Image-Guided I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery.

Dokumenttyp:
Journal Article
Autor(en):
Schug, Christina; Gupta, Aayush; Urnauer, Sarah; Steiger, Katja; Cheung, Phyllis Fung-Yi; Neander, Christian; Savvatakis, Konstantinos; Schmohl, Kathrin A; Trajkovic-Arsic, Marija; Schwenk, Nathalie; Schwaiger, Markus; Nelson, Peter J; Siveke, Jens T; Spitzweg, Christine
Abstract:
: The sodium iodide symporter () as theranostic gene would allow for non-invasive imaging of functional NIS expression and therapeutic radioiodine application. Genetically engineered mesenchymal stem cells (MSC), based on their tumor-homing abilities, show great promise as tumor-selective gene delivery vehicles for non-thyroidal tumors. As a next step towards clinical application, tumor specificity and efficacy of MSCs were investigated in an advanced genetically engineered mouse model of pancr...     »
Zeitschriftentitel:
Mol Cancer Res
Jahr:
2019
Band / Volume:
17
Heft / Issue:
1
Seitenangaben Beitrag:
310-320
Sprache:
eng
Volltext / DOI:
doi:10.1158/1541-7786.MCR-18-0185
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30224540
Print-ISSN:
1541-7786
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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