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- Dokumenttyp:
- Article; Journal Article; Research Support, Non-U.S. Gov't
- Autor(en):
- Zellmer, Stephan; Hanses, Frank; Muzalyova, Anna; Classen, Johanna; Braun, Georg; Piepel, Christiane; Erber, Johanna; Pilgram, Lisa; Walter, Lorenz; Göpel, Siri; Wille, Kai; Hower, Martin; Rüthrich, Maria Madeleine; Rupp, Jan; Degenhardt, Christian; Voigt, Ingo; Borgmann, Stefan; Stecher, Melanie; Jakob, Carolin; Dhillon, Christine; Messmann, Helmut; Ebigbo, Alanna; Römmele, Christoph
- Titel:
- Gastrointestinal bleeding and endoscopic findings in critically and non-critically ill patients with corona virus disease 2019 (COVID-19): Results from Lean European Open Survey on SARS-CoV-2 (LEOSS) and COKA registries.
- Abstract:
- BACKGROUND: Corona virus disease 2019 (COVID-19) patients are at increased risk for thromboembolic events. It is unclear whether the risk for gastrointestinal (GI) bleeding is also increased. METHODS: We considered 4128 COVID-19 patients enrolled in the Lean European Open Survey on SARS-CoV-2 (LEOSS) registry. The association between occurrence of GI bleeding and comorbidities as well as medication were examined. In addition, 1216 patients from COKA registry were analyzed focusing on endoscopy diagnostic findings. RESULTS: A cumulative number of 97 patients (1.8%) with GI bleeding were identified in the LEOSS registry and COKA registry. Of 4128 patients from the LEOSS registry, 66 patients (1.6%) had a GI bleeding. The rate of GI bleeding in patients with intensive care unit (ICU) admission was 4.5%. The use of therapeutic dose of anticoagulants showed a significant association with the increased incidence of bleeding in the critical phase of disease. The Charlson comorbidity index and the COVID-19 severity index were significantly higher in the group of patients with GI bleeding than in the group of patients without GI bleeding (5.83 (SD = 2.93) vs. 3.66 (SD = 3.06), p < 0.01 and 3.26 (SD = 1.69) vs. 2.33 (SD = 1.53), p < 0.01, respectively). In the COKA registry 31 patients (2.5%) developed a GI bleeding. Of these, the source of bleeding was identified in upper GI tract in 21 patients (67.7%) with ulcer as the most frequent bleeding source (25.8%, n = 8) followed by gastroesophageal reflux (16.1%, n = 5). In three patients (9.7%) GI bleeding source was located in lower GI tract caused mainly by diverticular bleeding (6.5%, n = 2). In seven patients (22.6%) the bleeding localization remained unknown. CONCLUSION: Consistent with previous research, comorbidities and disease severity correlate with the incidence of GI bleeding. Also, therapeutic anticoagulation seems to be associated with a higher risk of GI bleeding. Overall, the risk of GI bleeding seems not to be increased in COVID-19 patients.
- Zeitschriftentitel:
- United European Gastroenterol J
- Jahr:
- 2021
- Band / Volume:
- 9
- Heft / Issue:
- 9
- Seitenangaben Beitrag:
- 1081-1090
- Volltext / DOI:
- doi:10.1002/ueg2.12165
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/34655180
- Print-ISSN:
- 2050-6406
- TUM Einrichtung:
- II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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