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Title:

An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow

Document type:
Zeitschriftenaufsatz
Author(s):
Barbara Wirthl, Christina Janko, Stefan Lyer, Bernhard A. Schrefler, Christoph Alexiou, Wolfgang A. Wall
Abstract:
One of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target...     »
Keywords:
magnetic nanoparticles, magnetic drug targeting, multiphase porous media, tumour-growth model, cylindrical permanent magnet
Journal title:
Biomedical Microdevices
Year:
2024
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1007/s10544-023-00685-9
Status:
Verlagsversion / published
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