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Title:

Membrane lipid remodeling modulates γ-secretase processivity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dawkins, Edgar; Derks, Rico J E; Schifferer, Martina; Trambauer, Johannes; Winkler, Edith; Simons, Mikael; Paquet, Dominik; Giera, Martin; Kamp, Frits; Steiner, Harald
Abstract:
Imbalances in the amounts of amyloid-β peptides (Aβ) generated by the membrane proteases β- and γ-secretase are considered as a trigger of Alzheimer's disease (AD). Cell-free studies of γ-secretase have shown that increasing membrane thickness modulates Aβ generation but it has remained unclear if these effects are translatable to cells. Here we show that the very long-chain fatty acid erucic acid (EA) triggers acyl chain remodeling in AD cell models, resulting in substantial lipidome alteration...     »
Journal title abbreviation:
J Biol Chem
Year:
2023
Journal volume:
299
Journal issue:
4
Fulltext / DOI:
doi:10.1016/j.jbc.2023.103027
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36805335
Print-ISSN:
0021-9258
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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