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Titel:

MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making.

Dokumenttyp:
Article; Journal Article
Autor(en):
Metzger, Patrick; Hess, Maria Elena; Blaumeiser, Andreas; Pauli, Thomas; Schipperges, Vincent; Mertes, Ralf; Christoph, Jan; Unberath, Philipp; Reimer, Niklas; Scheible, Raphael; Illert, Anna L; Busch, Hauke; Andrieux, Geoffroy; Boerries, Melanie
Abstract:
(1) Background: Next-generation sequencing (NGS) of patients with advanced tumors is becoming an established method in Molecular Tumor Boards. However, somatic variant detection, interpretation, and report generation, require in-depth knowledge of both bioinformatics and oncology. (2) Methods: MIRACUM-Pipe combines many individual tools into a seamless workflow for comprehensive analyses and annotation of NGS data including quality control, alignment, variant calling, copy number variation estim...     »
Zeitschriftentitel:
Cancers (Basel)
Jahr:
2023
Band / Volume:
15
Heft / Issue:
13
Volltext / DOI:
doi:10.3390/cancers15133456
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37444566
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Lehrstuhl für Medizinische Informatik (Prof. Boeker); Professur für Personalisierte Onkologie (Prof. Illert)
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