HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study.

Uusitalo, Ulla; Mramba, Lazarus K; Aronsson, Carin Andrén; Vehik, Kendra; Yang, Jimin; Hummel, Sandra; Lernmark, Åke; Rewers, Marian; Hagopian, William; McIndoe, Richard; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Krischer, Jeffrey P; Virtanen, Suvi M; Norris, Jill M

doi:10.2337/dc23-0417

journal article

Titel:: HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study.
Dokumenttyp:: Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
Autor(en):: Uusitalo, Ulla; Mramba, Lazarus K; Aronsson, Carin Andrén; Vehik, Kendra; Yang, Jimin; Hummel, Sandra; Lernmark, Åke; Rewers, Marian; Hagopian, William; McIndoe, Richard; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Krischer, Jeffrey P; Virtanen, Suvi M; Norris, Jill M
Abstract:: OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children. RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA. CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.
Zeitschriftentitel:: Diabetes Care
Jahr:: 2023
Band / Volume:: 46
Heft / Issue:: 10
Seitenangaben Beitrag:: 1839-1847
Volltext / DOI:: doi:10.2337/dc23-0417
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/37579501
Print-ISSN:: 0149-5992
TUM Einrichtung:: Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer)2023