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Title:

The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tauber, Peter A; Kratzer, Bernhard; Schatzlmaier, Philipp; Smole, Ursula; Köhler, Cordula; Rausch, Lisa; Kranich, Jan; Trapin, Doris; Neunkirchner, Alina; Zabel, Maja; Jutz, Sabrina; Steinberger, Peter; Gadermaier, Gabriele; Brocker, Thomas; Stockinger, Hannes; Derdak, Sophia; Pickl, Winfried F
Abstract:
BACKGROUND: Treg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T lymphocytes has been demonstrated to critically participate in Treg development. OBJECTIVE: To evaluate small molecule inhibitors (SMI) for the identification of novel IL-2/Treg enhancing compounds. MATERIALS AND METHODS: We used TCR-dependent and allergen-specific cytokine secretion of human and mouse T cells, next generation messen...     »
Journal title abbreviation:
Front Immunol
Year:
2023
Journal volume:
14
Fulltext / DOI:
doi:10.3389/fimmu.2023.1094694
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37090735
Print-ISSN:
1664-3224
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland)
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