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Titel:

MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium.

Dokumenttyp:
Journal Article
Autor(en):
Singh, Anurag Kumar; Rai, Amrita; Weber, Anja; Gericke, Martin; Janssen, Klaus-Peter; Moser, Markus; Posern, Guido
Abstract:
The actin-regulated transcription factor MRTF-A represents a central relay in mechanotransduction and controls a subset of SRF-dependent target genes. However, gain-of-function studies in vivo are lacking. Here we characterize a conditional MRTF-A transgenic mouse model. While MRTF-A gain-of-function impaired embryonic development, induced expression of constitutively active MRTF-A provoked rapid hepatocyte ballooning and liver failure in adult mice. Specific expression in the intestinal epithel...     »
Zeitschriftentitel:
Cell Death Dis
Jahr:
2023
Band / Volume:
14
Heft / Issue:
9
Volltext / DOI:
doi:10.1038/s41419-023-06158-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37770456
TUM Einrichtung:
Klinik und Poliklinik für Chirurgie (Prof. Friess); Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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