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Title:

Slow integrin-dependent migration organizes networks of tissue-resident mast cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kaltenbach, Lukas; Martzloff, Paloma; Bambach, Sarah K; Aizarani, Nadim; Mihlan, Michael; Gavrilov, Alina; Glaser, Katharina M; Stecher, Manuel; Thünauer, Roland; Thiriot, Aude; Heger, Klaus; Kierdorf, Katrin; Wienert, Stephan; von Andrian, Ulrich H; Schmidt-Supprian, Marc; Nerlov, Claus; Klauschen, Frederick; Roers, Axel; Bajénoff, Marc; Grün, Dominic; Lämmermann, Tim
Abstract:
Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles of actin polymerization and actomyosin contraction1. Many immune cells do not necessarily require integrins, the major family of adhesion receptors in mammals, to move productively through three-dimensional tissue spaces2,3. Instead, they can use alternative strategies to transmit their actin-driven forces to the substrate, explaining their migratory adaptation to changing ext...     »
Journal title abbreviation:
Nat Immunol
Year:
2023
Journal volume:
24
Journal issue:
6
Pages contribution:
915-924
Fulltext / DOI:
doi:10.1038/s41590-023-01493-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37081147
Print-ISSN:
1529-2908
TUM Institution:
Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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