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Title:

E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.

Document type:
Article; Journal Article
Author(s):
Pruenster, Monika; Immler, Roland; Roth, Jonas; Kuchler, Tim; Bromberger, Thomas; Napoli, Matteo; Nussbaumer, Katrin; Rohwedder, Ina; Wackerbarth, Lou Martha; Piantoni, Chiara; Hennis, Konstantin; Fink, Diana; Kallabis, Sebastian; Schroll, Tobias; Masgrau-Alsina, Sergi; Budke, Agnes; Liu, Wang; Vestweber, Dietmar; Wahl-Schott, Christian; Roth, Johannes; Meissner, Felix; Moser, Markus; Vogl, Thomas; Hornung, Veit; Broz, Petr; Sperandio, Markus
Abstract:
S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers Bruton's tyrosine kinase-dependent tyrosine phosphorylation of NLRP3. Concomitant potas...     »
Journal title abbreviation:
Nat Immunol
Year:
2023
Journal volume:
24
Journal issue:
12
Pages contribution:
2021-2031
Fulltext / DOI:
doi:10.1038/s41590-023-01656-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37903858
Print-ISSN:
1529-2908
TUM Institution:
594; Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian); Professur für Nephrologie (Prof. Heemann)
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