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Title:

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Reinecke, Maria; Brear, Paul; Vornholz, Larsen; Berger, Benedict-Tilmann; Seefried, Florian; Wilhelm, Stephanie; Samaras, Patroklos; Gyenis, Laszlo; Litchfield, David William; Médard, Guillaume; Müller, Susanne; Ruland, Jürgen; Hyvönen, Marko; Wilhelm, Mathias; Kuster, Bernhard
Abstract:
Medicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical probes to study kinase biology. Because of polypharmacology, a large part of the human kinome currently lacks selective chemical probes. To discover such probes, we profiled 1,183 compounds from drug discovery projects in lysates of cancer cell lines using Kinobeads. The resulting 500,000 compound-target interactions are available in ProteomicsDB a...     »
Journal title abbreviation:
Nat Chem Biol
Year:
2024
Journal volume:
20
Journal issue:
5
Pages contribution:
577-585
Fulltext / DOI:
doi:10.1038/s41589-023-01459-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37904048
Print-ISSN:
1552-4450
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland)
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