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Title:

B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation.

Document type:
Journal Article
Author(s):
Gadjalova, Iana; Heinze, Julia M; Goess, Marie C; Hofmann, Julian; Buck, Annalisa; Weber, Marie-Christin; Blissenbach, Birgit; Kampick, Maximilian; Krut, Oleg; Steiger, Katja; Janssen, Klaus-Peter; Neumann, Philipp-Alexander; Ruland, Jürgen; Keppler, Selina J
Abstract:
Dysregulated B cell responses have been described in inflammatory bowel disease (IBD) patients; however, the role of B cells in IBD pathology remained incompletely understood. We here provide evidence for the detrimental role of activated B cells during the onset of autoimmune intestinal inflammation. Using Wiskott-Aldrich Syndrome interacting protein deficient (Wipf1-/-) mice as a mouse model of chronic colitis, we identified clusters of differentiation (CD)86 expression on activated B cells a...     »
Journal title abbreviation:
Mucosal Immunol
Year:
2024
Journal volume:
17
Journal issue:
1
Pages contribution:
67-80
Fulltext / DOI:
doi:10.1016/j.mucimm.2023.10.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37918715
Print-ISSN:
1933-0219
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Chirurgie (Prof. Friess)
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