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Titel:

B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation.

Dokumenttyp:
Journal Article
Autor(en):
Gadjalova, Iana; Heinze, Julia M; Goess, Marie C; Hofmann, Julian; Buck, Annalisa; Weber, Marie-Christin; Blissenbach, Birgit; Kampick, Maximilian; Krut, Oleg; Steiger, Katja; Janssen, Klaus-Peter; Neumann, Philipp-Alexander; Ruland, Jürgen; Keppler, Selina J
Abstract:
Dysregulated B cell responses have been described in inflammatory bowel disease (IBD) patients; however, the role of B cells in IBD pathology remained incompletely understood. We here provide evidence for the detrimental role of activated B cells during the onset of autoimmune intestinal inflammation. Using Wiskott-Aldrich Syndrome interacting protein deficient (Wipf1-/-) mice as a mouse model of chronic colitis, we identified clusters of differentiation (CD)86 expression on activated B cells a...     »
Zeitschriftentitel:
Mucosal Immunol
Jahr:
2024
Band / Volume:
17
Heft / Issue:
1
Seitenangaben Beitrag:
67-80
Volltext / DOI:
doi:10.1016/j.mucimm.2023.10.005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37918715
Print-ISSN:
1933-0219
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Chirurgie (Prof. Friess)
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