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Title:

Molecular Urothelial Tumor Cell Subtypes Remain Stable During Metastatic Evolution.

Document type:
Journal Article
Author(s):
Cox, Alexander; Klümper, Niklas; Stein, Johannes; Sikic, Danijel; Breyer, Johannes; Bolenz, Christian; Roghmann, Florian; Erben, Philipp; Wirtz, Ralph M; Wullich, Bernd; Ritter, Manuel; Hölzel, Michael; Schwamborn, Kristina; Horn, Thomas; Gschwend, Jürgen; Hartmann, Arndt; Weichert, Wilko; Erlmeier, Franziska; Eckstein, Markus
Abstract:
Urothelial cancer (UC) care is moving toward precision oncology. For tumor biology-driven treatment of metastatic UC (mUC), molecular subtypes play a crucial role. However, it is not known whether subtypes change during metastatic evolution. To address this, we analyzed a UC progression cohort (N = 154 patients) with 138 matched primary tumors (PRIM) and synchronous or metachronous distant metastasis (MET) by immunohistochemistry, and mRNA sequencing in a subgroup of 20 matched pairs. Protein-ba...     »
Journal title abbreviation:
Eur Urol
Year:
2024
Journal volume:
85
Journal issue:
4
Pages contribution:
328-332
Fulltext / DOI:
doi:10.1016/j.eururo.2023.03.020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37031005
Print-ISSN:
0302-2838
TUM Institution:
551; Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Urologie (Prof. Gschwend)
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