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Title:

Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens.

Document type:
Article; Comparative Study; Journal Article
Author(s):
Noske, Aurelia; Steiger, Katja; Ballke, Simone; Kiechle, Marion; Oettler, Dirk; Roth, Wilfried; Weichert, Wilko
Abstract:
AIMS: Programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer (TNBC) is important for immune checkpoint inhibitor therapies but may vary between different immunohistochemical assays, scorings and the type of specimen used for analysis. METHODS: We compared the analytical concordance of three clinically relevant PD-L1 assays (VENTANA SP142, VENTANA SP263 and DAKO 22C3 pharmDx) assessing immune cell score (IC), tumour proportion score and combined positive score (CPS) in preopera...     »
Journal title abbreviation:
J Clin Pathol
Year:
2024
Journal volume:
77
Journal issue:
4
Pages contribution:
239-245
Fulltext / DOI:
doi:10.1136/jcp-2022-208637
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36669878
Print-ISSN:
0021-9746
TUM Institution:
Klinik und Poliklinik für Frauenheilkunde (Prof. Kiechle)
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