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- Titel:
Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Mangarova, Dilyana Branimirova; Reimann, Carolin; Kaufmann, Jan Ole; Möckel, Jana; Kader, Avan; Adams, Lisa Christine; Ludwig, Antje; Onthank, David; Robinson, Simon; Karst, Uwe; Helmer, Rebecca; Botnar, Rene; Hamm, Bernd; Makowski, Marcus Richard; Brangsch, Julia
- Abstract:
- Atherosclerosis is a chronic inflammatory condition of the arteries and represents the primary cause of various cardiovascular diseases. Despite ongoing progress, finding effective anti-inflammatory therapeutic strategies for atherosclerosis remains a challenge. Here, we assessed the potential of molecular magnetic resonance imaging (MRI) to visualize the effects of 01BSUR, an anti-interleukin-1β monoclonal antibody, for treating atherosclerosis in a murine model. Male apolipoprotein E-deficient mice were divided into a therapy group (01BSUR, 2 × 0.3 mg/kg subcutaneously, n = 10) and control group (no treatment, n = 10) and received a high-fat diet for eight weeks. The plaque burden was assessed using an elastin-targeted gadolinium-based contrast probe (0.2 mmol/kg intravenously) on a 3 T MRI scanner. T1-weighted imaging showed a significantly lower contrast-to-noise (CNR) ratio in the 01BSUR group (pre: 3.93042664; post: 8.4007067) compared to the control group (pre: 3.70679168; post: 13.2982156) following administration of the elastin-specific MRI probe (p < 0.05). Histological examinations demonstrated a significant reduction in plaque size (p < 0.05) and a significant decrease in plaque elastin content (p < 0.05) in the treatment group compared to control animals. This study demonstrated that 01BSUR hinders the progression of atherosclerosis in a mouse model. Using an elastin-targeted MRI probe, we could quantify these therapeutic effects in MRI.
- Zeitschriftentitel:
- Sci Rep
- Jahr:
- 2024
- Band / Volume:
- 14
- Heft / Issue:
- 1
- Volltext / DOI:
- doi:10.1038/s41598-024-71716-5
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/39232217
- Print-ISSN:
- 2045-2322
- TUM Einrichtung:
- Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
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