BACKGROUND: Computed tomography (CT) relies on the attenuation of x-rays, and is, hence, of limited use for weakly attenuating organs of the body, such as the lung. X-ray dark-field (DF) imaging is a recently developed technology that utilizes x-ray optical gratings to enable small-angle scattering as an alternative contrast mechanism. The DF signal provides structural information about the micromorphology of an object, complementary to the conventional attenuation signal. A first human-scale x-ray DF CT has been developed by our group. Despite specialized processing algorithms, reconstructed images remain affected by streaking artifacts, which often hinder image interpretation. In recent years, convolutional neural networks have gained popularity in the field of CT reconstruction, amongst others for streak artefact removal. PURPOSE: Reducing streak artifacts is essential for the optimization of image quality in DF CT, and artefact free images are a prerequisite for potential future clinical application. The purpose of this paper is to demonstrate the feasibility of CNN post-processing for artefact reduction in x-ray DF CT and how multi-rotation scans can serve as a pathway for training data. METHODS: We employed a supervised deep-learning approach using a three-dimensional dual-frame UNet in order to remove streak artifacts. Required training data were obtained from the experimental x-ray DF CT prototype at our institute. Two different operating modes were used to generate input and corresponding ground truth data sets. Clinically relevant scans at dose-compatible radiation levels were used as input data, and extended scans with substantially fewer artifacts were used as ground truth data. The latter is neither dose-, nor time-compatible and, therefore, unfeasible for clinical imaging of patients. RESULTS: The trained CNN was able to greatly reduce streak artifacts in DF CT images. The network was tested against images with entirely different, previously unseen image characteristics. In all cases, CNN processing substantially increased the image quality, which was quantitatively confirmed by increased image quality metrics. Fine details are preserved during processing, despite the output images appearing smoother than the ground truth images. CONCLUSIONS: Our results showcase the potential of a neural network to reduce streak artifacts in x-ray DF CT. The image quality is successfully enhanced in dose-compatible x-ray DF CT, which plays an essential role for the adoption of x-ray DF CT into modern clinical radiology.      «

BACKGROUND: Computed tomography (CT) relies on the attenuation of x-rays, and is, hence, of limited use for weakly attenuating organs of the body, such as the lung. X-ray dark-field (DF) imaging is a recently developed technology that utilizes x-ray optical gratings to enable small-angle scattering as an alternative contrast mechanism. The DF signal provides structural information about the micromorphology of an object, complementary to the conventional attenuation signal. A first human-scale x-...     »