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Titel:

Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Wiechmann, Svenja; Saupp, Elena; Schilling, Daniela; Heinzlmeir, Stephanie; Schneider, Günter; Schmid, Roland M.; Combs, Stephanie E.; Kuster, Bernhard; Dobiasch, Sophie
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers and known for its extensive genetic heterogeneity, high therapeutic resistance, and strong variation in intrinsic radiosensitivity. To understand the molecular mechanisms underlying radioresistance, we screened the phenotypic response of 38 PDAC cell lines to ionizing radiation. Subsequent phosphoproteomic analysis of two representative sensitive and resistant lines led to the reproducible identification of 7,800 prote...     »
Stichworte:
BayBioMS, Pancreatic cancer; cancer therapeutics; enzyme inhibition; kinase inhibitors; kinase substrates; kinases; phosphoproteome; radioresistance.
Zeitschriftentitel:
Molecular & Cellular Proteomics
Jahr:
2020
Band / Volume:
19
Heft / Issue:
10
Seitenangaben Beitrag:
1649-1663
Volltext / DOI:
doi:10.1074/mcp.ra120.002046
Verlag / Institution:
Elsevier BV
E-ISSN:
1535-9476
Publikationsdatum:
01.10.2020
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