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Titel:

Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Liskiewicz, D; Zhang, Q; Barthem, C S; Jastroch, M; Liskiewicz, A; Khajavi, N; Grandl, G; Coupland, C; Kleinert, M; Garcia-Caceres, C; Novikoff, A; Maity, G; Boehm, U; Tschöp, M H; Müller, T D
Abstract:
OBJECTIVE: Mice with global deletion of the transient receptor potential channel melastatin family member 8 (TRPM8) are obese, and treatment of diet-induced obese (DIO) mice with TRPM8 agonists decrease body weight. Whether TRPM8 signaling regulates energy metabolism via central or peripheral effects is unknow. Here we assessed the metabolic phenotype of mice with either Nestin Cre-mediated neuronal loss of TRPM8, or with deletion of TRPM8 in Advillin Cre positive sensory neurons of the peripher...     »
Zeitschriftentitel:
Mol Metab
Jahr:
2023
Band / Volume:
72
Volltext / DOI:
doi:10.1016/j.molmet.2023.101714
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36966947
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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