Antibiotic Treatment During Pregnancy and the First Six Months Postpartum - a Secondary Analysis of the "Healthy Living in Pregnancy" (GeliS) Study.

Knoke, Johanna; Raab, Roxana; Geyer, Kristina; Spies, Monika; Haller, Bernhard; Hauner, Hans

doi:10.1055/a-2091-0620

2023

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Titel:: Antibiotic Treatment During Pregnancy and the First Six Months Postpartum - a Secondary Analysis of the "Healthy Living in Pregnancy" (GeliS) Study.
Dokumenttyp:: Article; Journal Article
Autor(en):: Knoke, Johanna; Raab, Roxana; Geyer, Kristina; Spies, Monika; Haller, Bernhard; Hauner, Hans
Abstract:: INTRODUCTION: Antibiotic therapies for the treatment of bacterial infections pose a particular challenge during pregnancy and breastfeeding. For Germany, there is hardly any information on the frequency of antibiotic use during this phase. Our analysis uses data from the "Healthy Living in Pregnancy" (GeliS) study to describe antibiotic treatments during pregnancy and in the first six months after birth (postpartum), and to compare their use with existing recommendations. METHODS: This is a retrospective secondary analysis of the GeliS study. In the cluster randomized lifestyle intervention study, detailed information on antibiotic therapies during pregnancy and postpartum was collected using surveys. Chi-square tests and generalized estimating equations were used for evaluation. RESULTS: Of the 1636 women included in the analysis, 21% reported antibiotic treatment at least once during pregnancy (14%) or in the first six months postpartum (7%). During pregnancy, the antibiotic therapies of women increased from 1.7% in the first trimester to 6.5% in the third trimester. Common reasons for treatment were urinary tract infections (7.3% of women), ear, nose, throat (ENT) infections (3.6%), and birth complications (2.6%). The information on the prescribed preparations corresponded to the current recommendations. A significant increase in the frequency of treatment with antibiotics was observed in the lifestyle intervention group (p < 0.001), in participants without a partner (p < 0.001), and in women who breastfed their children (p = 0.005) or gave birth by caesarean section (p = 0.003) or prematurely (p = 0.012). Other socioeconomic or lifestyle factors were not significant. CONCLUSION: Approximately one in five women receives at least one antibiotic treatment during pregnancy and breastfeeding that meets current treatment recommendations. Treatment with antibiotics is more common in premature births, caesarean sections, and breastfeeding women.
Zeitschriftentitel:: Geburtsh Frauenheilk
Jahr:: 2023
Band / Volume:: 83
Heft / Issue:: 7
Seitenangaben Beitrag:: 850-861
Volltext / DOI:: doi:10.1055/a-2091-0620
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/37564896
Print-ISSN:: 0016-5751
TUM Einrichtung:: Klinik für Ernährungsmedizin (Prof. Hauner); Lehrstuhl für Medizinische Informatik (Prof. Boeker)
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