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Title:

Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler.

Document type:
Journal Article
Author(s):
Laber, Samantha; Strobel, Sophie; Mercader, Josep M; Dashti, Hesam; Dos Santos, Felipe R C; Kubitz, Phil; Jackson, Maya; Ainbinder, Alina; Honecker, Julius; Agrawal, Saaket; Garborcauskas, Garrett; Stirling, David R; Leong, Aaron; Figueroa, Katherine; Sinnott-Armstrong, Nasa; Kost-Alimova, Maria; Deodato, Giacomo; Harney, Alycen; Way, Gregory P; Saadat, Alham; Harken, Sierra; Reibe-Pal, Saskia; Ebert, Hannah; Zhang, Yixin; Calabuig-Navarro, Virtu; McGonagle, Elizabeth; Stefek, Adam; Dupuis, José...     »
Abstract:
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by genetic risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands of morphological and cellular profiles that can be systematically linked to genes and genetic variants relevant to cardiometabolic disease. We show that LipocytePro...     »
Journal title abbreviation:
Cell Genom
Year:
2023
Journal volume:
3
Journal issue:
7
Fulltext / DOI:
doi:10.1016/j.xgen.2023.100346
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37492099
TUM Institution:
Klinik für Ernährungsmedizin (Prof. Hauner)
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