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Title:

A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Glunk, Viktoria; Laber, Samantha; Sinnott-Armstrong, Nasa; Sobreira, Debora R; Strobel, Sophie M; Batista, Thiago M; Kubitz, Phil; Moud, Bahareh Nemati; Ebert, Hannah; Huang, Yi; Brandl, Beate; Garbo, Garrett; Honecker, Julius; Stirling, David R; Abdennur, Nezar; Calabuig-Navarro, Virtu; Skurk, Thomas; Ocvirk, Soeren; Stemmer, Kerstin; Cimini, Beth A; Carpenter, Anne E; Dankel, Simon N; Lindgren, Cecilia M; Hauner, Hans; Nobrega, Marcelo A; Claussnitzer, Melina
Abstract:
Recent large-scale genomic association studies found evidence for a genetic link between increased risk of type 2 diabetes and decreased risk for adiposity-related traits, reminiscent of metabolically obese normal weight (MONW) association signatures. However, the target genes and cellular mechanisms driving such MONW associations remain to be identified. Here, we systematically identify the cellular programmes of one of the top-scoring MONW risk loci, the 2q24.3 risk locus, in subcutaneous adip...     »
Journal title abbreviation:
Nat Metab
Year:
2023
Journal volume:
5
Journal issue:
5
Pages contribution:
861-879
Fulltext / DOI:
doi:10.1038/s42255-023-00807-w
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37253881
TUM Institution:
Klinik für Ernährungsmedizin (Prof. Hauner)
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