High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon.

Schoenfeld, Julia; Roeh, Astrid; Holdenrieder, Stefan; von Korn, Pia; Haller, Bernhard; Krueger, Kimberly; Falkai, Peter; Halle, Martin; Hasan, Alkomiet; Scherr, Johannes

doi:10.3389/fphys.2023.1118127

journal article

Title:: High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon.
Document type:: Journal Article
Author(s):: Schoenfeld, Julia; Roeh, Astrid; Holdenrieder, Stefan; von Korn, Pia; Haller, Bernhard; Krueger, Kimberly; Falkai, Peter; Halle, Martin; Hasan, Alkomiet; Scherr, Johannes
Abstract:: Background: Prolonged and strenuous exercise has been linked to potential exercise-induced myocardial damages. One potential key to unmask the discussed underlying mechanisms of this subclinical cardiac damage could be markers of immunogenic cell damage (ICD). We investigated the kinetics of high-mobility group box 1 protein (HMGB1), soluble receptor for advanced glycation end products (sRAGE), nucleosomes, high sensitive troponin T (hs-TnT) and high sensitive C-reactive protein (hs-CRP) before and up to 12 weeks post-race and described associations with routine laboratory markers and physiological covariates. Methods: In our prospective longitudinal study, 51 adults (82% males; 43 ± 9 years) were included. All participants underwent a cardiopulmonary evaluation 10-12 weeks pre-race. HMGB1, sRAGE, nucleosomes, hs-TnT and, hs-CRP were analysed 10-12 weeks prior, 1-2 weeks before, immediately, 24 h, 72 h, and 12 weeks post-race. Results: HMGB1, sRAGE, nucleosomes and hs-TnT increased significantly from pre- to immediately post-race (0.82-2.79 ng/mL; 1132-1388 pg/mL; 9.24-56.65 ng/mL; 6-27 ng/L; p < 0.001) and returned to baseline within 24-72 h. Hs-CRP increased significantly 24 h post-race (0.88-11.5 mg/L; p < 0.001). Change in sRAGE was positively associated with change in hs-TnT (rs = 0.352, p = 0.011). Longer marathon finishing time was significantly associated with decreased levels of sRAGE [-9.2 pg/mL (β = -9.2, SE = 2.2, p < 0.001)]. Conclusion: Prolonged and strenuous exercise increases markers of ICD immediately post-race, followed by a decrease within 72 h. An acute marathon event results in transient alterations of ICD, we assume that this is not solely driven by myocyte damages.
Journal title abbreviation:: Front Physiol
Year:: 2023
Journal volume:: 14
Fulltext / DOI:: doi:10.3389/fphys.2023.1118127
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/36866178
Print-ISSN:: 1664-042X
TUM Institution:: Lehrstuhl für Medizinische Informatik (Prof. Boeker); Poliklinik für Präventive Sportmedizin und Sportkardiologie (Prof. Halle)
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