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Titel:

Interleukin-10 -1082 G/A polymorphism and its association with early or severe presentation of coronary artery disease: A systematic review and meta-analysis.

Dokumenttyp:
Meta-Analysis; Systematic Review; Journal Article; Review
Autor(en):
Rai, Himanshu; Joner, Michael; Wilson, Hannah; McGovern, Laurna; Richards, Gavin; Colleran, Roisin; Byrne, Robert A
Abstract:
INTRODUCTION: Interleukin-10 (IL-10) is an anti-inflammatory cytokine with potent deactivating properties on macrophages and T cells; and plays an important role in atherosclerotic plaque maturation and rupture. A guanine (G) to adenine (A) substitution in the IL-10 gene at -1082 bp (rs1800896) has been associated with reduced in IL-10 production in vitro. Against this background, we tested the association of IL-10 -1082G/A with early or severe presentation of coronary artery disease (CAD) usin...     »
Zeitschriftentitel:
Cytokine
Jahr:
2023
Band / Volume:
162
Volltext / DOI:
doi:10.1016/j.cyto.2022.156103
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36463660
Print-ISSN:
1043-4666
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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