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Titel:

ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Sharifi, M Amin; Wierer, Michael; Dang, Tan An; Milic, Jelena; Moggio, Aldo; Sachs, Nadja; von Scheidt, Moritz; Hinterdobler, Julia; Müller, Philipp; Werner, Julia; Stiller, Barbara; Aherrahrou, Zouhair; Erdmann, Jeanette; Zaliani, Andrea; Graettinger, Mira; Reinshagen, Jeanette; Gul, Sheraz; Gribbon, Philip; Maegdefessel, Lars; Bernhagen, Jürgen; Sager, Hendrik B; Mann, Matthias; Schunkert, Heribert; Kessler, Thorsten
Abstract:
BACKGROUND: The ADAMTS7 locus was genome-wide significantly associated with coronary artery disease. Lack of the ECM (extracellular matrix) protease ADAMTS-7 (A disintegrin and metalloproteinase-7) was shown to reduce atherosclerotic plaque formation. Here, we sought to identify molecular mechanisms and downstream targets of ADAMTS-7 mediating the risk of atherosclerosis. METHODS: Targets of ADAMTS-7 were identified by high-resolution mass spectrometry of atherosclerotic plaques from Apoe-/- and...     »
Zeitschriftentitel:
Circ Res
Jahr:
2023
Band / Volume:
133
Heft / Issue:
8
Seitenangaben Beitrag:
674-686
Volltext / DOI:
doi:10.1161/CIRCRESAHA.123.322737
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37675562
Print-ISSN:
0009-7330
TUM Einrichtung:
657; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert); Professur für Vaskuläre Biologie (Prof. Maegdefessel)
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