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Titel:

Rapid Diagnostic Platform for Personalized Vitamin B6 Detection in Erythrocytes via PLP Cofactor Mimics.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Fiedler, Michaela K; Drechsel, Jonas; Schmidt, Ronny; Luppa, Peter B; Bach, Nina C; Sieber, Stephan A
Abstract:
Personalized assessment of vitamin levels in point-of-care (POC) devices is urgently needed to advance the recognition of diseases associated with malnutrition and unbalanced diets. We here introduce a diagnostic platform, which showcases an easy and rapid readout of vitamin B6 (pyridoxal phosphate, PLP) levels in erythrocytes as a first step toward a home-use POC. The technology is based on fluorescent probes, which bind to PLP-dependent enzymes (PLP-DEs) and thereby indirectly report their occ...     »
Zeitschriftentitel:
ACS Chem Biol
Jahr:
2023
Band / Volume:
18
Heft / Issue:
7
Seitenangaben Beitrag:
1653-1660
Volltext / DOI:
doi:10.1021/acschembio.3c00279
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37406307
Print-ISSN:
1554-8929
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland)
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