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Dokumenttyp:
Journal Article
Autor(en):
Varela-Moreira, Aida; van Leur, Heleen; Krijgsman, Danielle; Ecker, Veronika; Braun, Martina; Buchner, Maike; Fens, Marcel H A M; Hennink, Wim E; Schiffelers, Raymond M
Titel:
Utilizing in vitro drug release assays to predict in vivo drug retention in micelles.
Abstract:
In the present work, we aim at developing an in vitro release assay to predict circulation times of hydrophobic drugs loaded into polymeric micelles (PM), upon intravenous (i.v.) administration. PM based on poly (ethylene glycol)-b-poly (N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) block copolymer were loaded with a panel of hydrophobic anti-cancer drugs and characterized for size, loading efficiency and release profile in different release media. Circulation times in mice of two sel...     »
Zeitschriftentitel:
Int J Pharm
Jahr:
2022
Band / Volume:
618
Volltext / DOI:
doi:10.1016/j.ijpharm.2022.121638
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35257802
Print-ISSN:
0378-5173
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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