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Titel:

Molecular mechanisms of leukocyte β2 integrin activation.

Dokumenttyp:
Journal Article; Review
Autor(en):
Wen, Lai; Moser, Markus; Ley, Klaus
Abstract:
Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Although all integrins can undergo activation (affinity change for ligands), the degree of activation is most spectacular for integrins on blood cells. The β2 integrins are exclusively expressed on the surface of all leukocytes including neutrophils, lymphocytes, and monocytes. They are essential for many leukocyte functions and are strictly required for neutrophil arrest from rolling. The inside...     »
Zeitschriftentitel:
Blood
Jahr:
2022
Band / Volume:
139
Heft / Issue:
24
Seitenangaben Beitrag:
3480-3492
Volltext / DOI:
doi:10.1182/blood.2021013500
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35167661
Print-ISSN:
0006-4971
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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