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Titel:

The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation.

Dokumenttyp:
Journal Article
Autor(en):
Borza, Corina M; Bolas, Gema; Zhang, Xiuqi; Browning Monroe, Mary Beth; Zhang, Ming-Zhi; Meiler, Jens; Skwark, Marcin J; Harris, Raymond C; Lapierre, Lynne A; Goldenring, James R; Hook, Magnus; Rivera, Jose; Brown, Kyle L; Leitinger, Birgit; Tyska, Matthew J; Moser, Markus; Böttcher, Ralph T; Zent, Roy; Pozzi, Ambra
Abstract:
Integrins and discoidin domain receptors (DDRs) 1 and 2 promote cell adhesion and migration on both fibrillar and non fibrillar collagens. Collagen I contains DDR and integrin selective binding motifs; however, the relative contribution of these two receptors in regulating cell migration is unclear. DDR1 has five isoforms (DDR1a-e), with most cells expressing the DDR1a and DDR1b isoforms. We show that human embryonic kidney 293 cells expressing DDR1b migrate more than DDR1a expressing cells on...     »
Zeitschriftentitel:
Front Cell Dev Biol
Jahr:
2022
Band / Volume:
10
Volltext / DOI:
doi:10.3389/fcell.2022.836797
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35309920
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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