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Title:

Cut loose TIMP-1: an emerging cytokine in inflammation.

Document type:
Review; Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Schoeps, Benjamin; Frädrich, Julian; Krüger, Achim
Abstract:
Appreciation of the entire biological impact of an individual protein can be hampered by its original naming based on one function only. Tissue inhibitor of metalloproteinases-1 (TIMP-1), mostly known for its eponymous function to inhibit metalloproteinases, exhibits only a fraction of its cellular effects via this feature. Recently, TIMP-1 emerged as a potent cytokine acting via various cell-surface receptors, explaining a so-far under-appreciated role of TIMP-1-mediated signaling on immune cel...     »
Journal title abbreviation:
Trends Cell Biol
Year:
2023
Journal volume:
33
Journal issue:
5
Pages contribution:
413-426
Fulltext / DOI:
doi:10.1016/j.tcb.2022.08.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36163148
Print-ISSN:
0962-8924
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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