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Titel:

TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Eckfeld, Celina; Schoeps, Benjamin; Häußler, Daniel; Frädrich, Julian; Bayerl, Felix; Böttcher, Jan Philipp; Knolle, Percy; Heisz, Simone; Prokopchuk, Olga; Hauner, Hans; Munkhbaatar, Enkhtsetseg; Demir, Ihsan Ekin; Hermann, Chris D; Krüger, Achim
Abstract:
The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are largely unknown. Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor Protein (APP) family members, namely APP and Amyloid Precursor-like Protein-2 (APLP2), which was confirmed by pull-down assays and confocal micr...     »
Zeitschriftentitel:
J Cell Biol
Jahr:
2023
Band / Volume:
222
Heft / Issue:
2
Volltext / DOI:
doi:10.1083/jcb.202206095
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36629908
Print-ISSN:
0021-9525
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie (Prof. Friess); Roman Herzog Comprehensive Cancer Center
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