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Title:

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume.

Document type:
Journal Article
Author(s):
Lauerer, Markus; Bussas, Matthias; Pongratz, Viola; Berthele, Achim; Kirschke, Jan S; Wiestler, Benedikt; Zimmer, Claus; Hemmer, Bernhard; Mühlau, Mark
Abstract:
Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing-remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortic...     »
Journal title abbreviation:
Ann Clin Transl Neurol
Year:
2023
Journal volume:
10
Journal issue:
1
Pages contribution:
130-135
Fulltext / DOI:
doi:10.1002/acn3.51700
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36427289
TUM Institution:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Professur für AI for Image-Guided Diagnosis and Therapy (Prof. Wiestler); Professur für Neuroradiologie (Prof. Zimmer)
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