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Titel:

Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.

Dokumenttyp:
Article; Journal Article
Autor(en):
Maity-Kumar, Gandhari; Ständer, Lisa; DeAngelis, Meri; Lee, Sooyeon; Molenaar, Anna; Becker, Lore; Garrett, Lillian; Amerie, Oana V; Hoelter, Sabine M; Wurst, Wolfgang; Fuchs, Helmut; Feuchtinger, Annette; Gailus-Durner, Valerie; Garcia-Caceres, Cristina; Othman, Ahmed E; Brockmann, Caroline; Schöffling, Vanessa I; Beiser, Katja; Krude, Heiko; Mroz, Piotr A; Hofmann, Susanna; Tuckermann, Jan; DiMarchi, Richard D; Hrabe de Angelis, Martin; Tschöp, Matthias H; Pfluger, Paul T; Müller, Timo D
Abstract:
OBJECTIVE: The Allan-Herndon-Dudley syndrome (AHDS) is a severe disease caused by dysfunctional central thyroid hormone transport due to functional loss of the monocarboxylate transporter 8 (MCT8). In this study, we assessed whether mice with concomitant deletion of the thyroid hormone transporters Mct8 and the organic anion transporting polypeptide (Oatp1c1) represent a valid preclinical model organism for the AHDS. METHODS: We generated and metabolically characterized a new CRISPR/Cas9 generat...     »
Zeitschriftentitel:
Mol Metab
Jahr:
2022
Band / Volume:
66
Volltext / DOI:
doi:10.1016/j.molmet.2022.101616
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36270613
TUM Einrichtung:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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