Altered gray-to-white matter tissue contrast in preterm-born adults.

Schmitz-Koep, Benita; Menegaux, Aurore; Zimmermann, Juliana; Thalhammer, Melissa; Neubauer, Antonia; Wendt, Jil; Schinz, David; Daamen, Marcel; Boecker, Henning; Zimmer, Claus; Priller, Josef; Wolke, Dieter; Bartmann, Peter; Sorg, Christian; Hedderich, Dennis M

doi:10.1111/cns.14320

2023

Back
Back to start of result list
Permanent link for displayed object

Title:: Altered gray-to-white matter tissue contrast in preterm-born adults.
Document type:: Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Schmitz-Koep, Benita; Menegaux, Aurore; Zimmermann, Juliana; Thalhammer, Melissa; Neubauer, Antonia; Wendt, Jil; Schinz, David; Daamen, Marcel; Boecker, Henning; Zimmer, Claus; Priller, Josef; Wolke, Dieter; Bartmann, Peter; Sorg, Christian; Hedderich, Dennis M
Abstract:: AIMS: To investigate cortical organization in brain magnetic resonance imaging (MRI) of preterm-born adults using percent contrast of gray-to-white matter signal intensities (GWPC), which is an in vivo proxy measure for cortical microstructure. METHODS: Using structural MRI, we analyzed GWPC at different percentile fractions across the cortex (0%, 10%, 20%, 30%, 40%, 50%, and 60%) in a large and prospectively collected cohort of 86 very preterm-born (<32 weeks of gestation and/or birth weight <1500 g, VP/VLBW) adults and 103 full-term controls at 26 years of age. Cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. RESULTS: GWPC was significantly decreased in VP/VLBW adults in frontal, parietal, and temporal associative cortices, predominantly in the right hemisphere. Differences were pronounced at 20%, 30%, and 40%, hence, in middle cortical layers. GWPC was significantly increased in right paracentral lobule in VP/VLBW adults. GWPC in frontal and temporal cortices was positively correlated with birth weight, and negatively with duration of ventilation (p < 0.05). Furthermore, GWPC in right paracentral lobule was negatively correlated with IQ (p < 0.05). CONCLUSIONS: Widespread aberrant gray-to-white matter contrast suggests lastingly altered cortical microstructure after preterm birth, mainly in middle cortical layers, with differential effects on associative and primary cortices.
Journal title abbreviation:: CNS Neurosci Ther
Year:: 2023
Journal volume:: 29
Journal issue:: 11
Pages contribution:: 3199-3211
Fulltext / DOI:: doi:10.1111/cns.14320
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/37365964
Print-ISSN:: 1755-5930
TUM Institution:: Klinik und Poliklinik für Psychiatrie und Psychotherapie (Prof. Priller); Professur für Neuroradiologie (Prof. Zimmer)
BibTeX