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Titel:

Oncogenic KRAS and the EGFR loop in pancreatic carcinogenesis-A connection to licensing nodes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Schneeweis, Christian; Wirth, Matthias; Saur, Dieter; Reichert, Maximilian; Schneider, Günter
Abstract:
EGFR signaling has a critical role in oncogenic KRAS-driven tumorigenesis of the pancreas, whereas it is dispensable in other organs. The complex signaling network engaged by oncogenic KRAS and its modulation by EGFR signaling, remains incompletely understood. In order to study early signaling events activated by oncogenic KRAS in the pancreas, we recently developed a novel model system based on murine primary pancreatic epithelial cells enabling the time-specific expression of mutant KrasG12D f...     »
Zeitschriftentitel:
Small GTPases
Jahr:
2018
Band / Volume:
9
Heft / Issue:
6
Seitenangaben Beitrag:
457-464
Sprache:
eng
Volltext / DOI:
doi:10.1080/21541248.2016.1262935
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27880072
Print-ISSN:
2154-1248
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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