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Titel:

SMAD4 Loss Induces c-MYC-Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis.

Dokumenttyp:
Journal Article
Autor(en):
Loevenich, Leon P; Tschurtschenthaler, Markus; Rokavec, Matjaz; Silva, Miguel G; Jesinghaus, Moritz; Kirchner, Thomas; Klauschen, Frederick; Saur, Dieter; Neumann, Jens; Hermeking, Heiko; Jung, Peter
Abstract:
UNLABELLED: Growth and metastasis of colorectal cancer is closely connected to the biosynthetic capacity of tumor cells, and colorectal cancer stem cells that reside at the top of the intratumoral hierarchy are especially dependent on this feature. By performing disease modeling on patient-derived tumor organoids, we found that elevated expression of the ribosome biogenesis factor NLE1 occurs upon SMAD4 loss in TGFβ1-exposed colorectal cancer organoids. TGFβ signaling-mediated downregulation of...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2022
Band / Volume:
82
Heft / Issue:
24
Seitenangaben Beitrag:
4604-4623
Volltext / DOI:
doi:10.1158/0008-5472.CAN-22-1247
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36219392
Print-ISSN:
0008-5472
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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