Extensive 177Lu-PSMA Radioligand Therapy Can Lead to Radiation Nephropathy with a Renal Thrombotic Microangiopathy-like Picture.

Schäfer, Hannah; Mayr, Sarah; Büttner-Herold, Maike; Knorr, Karina; Steinhelfer, Lisa; Böger, Carsten A; Gschwend, Jürgen E; Heemann, Uwe; Eiber, Matthias; Schmaderer, Christoph; Tauber, Robert

doi:10.1016/j.eururo.2022.05.025

Abteilung für Nephrologie (Prof. Heemann)

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Titel:: Extensive 177Lu-PSMA Radioligand Therapy Can Lead to Radiation Nephropathy with a Renal Thrombotic Microangiopathy-like Picture.
Dokumenttyp:: Case Reports
Autor(en):: Schäfer, Hannah; Mayr, Sarah; Büttner-Herold, Maike; Knorr, Karina; Steinhelfer, Lisa; Böger, Carsten A; Gschwend, Jürgen E; Heemann, Uwe; Eiber, Matthias; Schmaderer, Christoph; Tauber, Robert
Abstract:: Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA) radioligand therapy is an option that is increasingly being used for treatment of metastatic castration-resistant prostate cancer. This delivers β-radiation to cells expressing PSMA and high accumulation of the radiopharmaceutical occurs in the kidneys. Here we report three cases of radiation nephropathy with severe chronic kidney disease induced by renal thrombotic microangiopathy following extensive treatment with 177Lu-PSMA radioligand therapy. «
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA) radioligand therapy is an option that is increasingly being used for treatment of metastatic castration-resistant prostate cancer. This delivers β-radiation to cells expressing PSMA and high accumulation of the radiopharmaceutical occurs in the kidneys. Here we report three cases of radiation nephropathy with severe chronic kidney disease induced by renal thrombotic microangiopathy following extensive treatment with 177Lu-PSMA radiolig... »
Zeitschriftentitel:: Eur Urol
Jahr:: 2023
Band / Volume:: 83
Heft / Issue:: 5
Seitenangaben Beitrag:: 385-390
Volltext / DOI:: doi:10.1016/j.eururo.2022.05.025
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/35688660
Print-ISSN:: 0302-2838
TUM Einrichtung:: Klinik und Poliklinik für Nuklearmedizin (Prof. Weber); Klinik und Poliklinik für Urologie (Prof. Gschwend); Professur für Nephrologie (Prof. Heemann)
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