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Title:

NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Laudenbach, Beatrice T; Krey, Karsten; Emslander, Quirin; Andersen, Line Lykke; Reim, Alexander; Scaturro, Pietro; Mundigl, Sarah; Dächert, Christopher; Manske, Katrin; Moser, Markus; Ludwig, Janos; Wohlleber, Dirk; Kröger, Andrea; Binder, Marco; Pichlmair, Andreas
Abstract:
While viral replication processes are largely understood, comparably little is known on cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5'-triphosphate (PPP-) group that impairs degradation by the canonical 5'-3' degradation pathway. Here we show that the Nudix hydrolase 2 (NUDT2) trims viral PPP-RNA into monophosphorylated (P)-RNA, which serves as a substrate for the 5'-3' exonuclease XRN1. NUDT2 removes 5'-phosphates from PPP-RNA in an RNA sequence- and overhang-independent man...     »
Journal title abbreviation:
Nat Commun
Year:
2021
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-27239-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34824277
Print-ISSN:
2041-1723
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Roman Herzog Comprehensive Cancer Center
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