Comparison of Novel Volumetric Microperimetry Metrics in Intermediate Age-Related Macular Degeneration: PINNACLE Study Report 3.

Anders, Philipp; Traber, Ghislaine L; Pfau, Maximilian; Riedl, Sophie; Hagag, Ahmed M; Camenzind, Hanna; Mai, Julia; Kaye, Rebecca; Bogunovic, Hrvoje; Fritsche, Lars G; Rueckert, Daniel; Schmidt-Erfurth, Ursula; Sivaprasad, Sobha; Lotery, Andrew J; Scholl, Hendrik P N

doi:10.1167/tvst.12.8.21

2023

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Titel:: Comparison of Novel Volumetric Microperimetry Metrics in Intermediate Age-Related Macular Degeneration: PINNACLE Study Report 3.
Dokumenttyp:: Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Anders, Philipp; Traber, Ghislaine L; Pfau, Maximilian; Riedl, Sophie; Hagag, Ahmed M; Camenzind, Hanna; Mai, Julia; Kaye, Rebecca; Bogunovic, Hrvoje; Fritsche, Lars G; Rueckert, Daniel; Schmidt-Erfurth, Ursula; Sivaprasad, Sobha; Lotery, Andrew J; Scholl, Hendrik P N
Abstract:: PURPOSE: To investigate and compare novel volumetric microperimetry (MP)-derived metrics in intermediate age-related macular degeneration (iAMD), as current MP metrics show high variability and low sensitivity. METHODS: This is a cross-sectional analysis of microperimetry baseline data from the multicenter, prospective PINNACLE study (ClinicalTrials.gov NCT04269304). The Visual Field Modeling and Analysis (VFMA) software and an open-source implementation (OSI) were applied to calculate MP-derived hill-of-vison (HOV) surface plots and the total volume (VTOT) beneath the plots. Bland-Altman plots were used for methodologic comparison, and the association of retinal sensitivity metrics with explanatory variables was tested with mixed-effects models. RESULTS: In total, 247 eyes of 189 participants (75 ± 7.3 years) were included in the analysis. The VTOT output of VFMA and OSI exhibited a significant difference (P < 0.0001). VFMA yielded slightly higher coefficients of determination than OSI and mean sensitivity (MS) in univariable and multivariable modeling, for example, in association with low-luminance visual acuity (LLVA) (marginal R2/conditional R2: VFMA 0.171/0.771, OSI 0.162/0.765, MS 0.133/0.755). In the multivariable analysis, LLVA was the only demonstrable predictor of VFMA VTOT (t-value, P-value: -7.5, <0.001) and MS (-6.5, <0.001). CONCLUSIONS: The HOV-derived metric of VTOT exhibits favorable characteristics compared to MS in evaluating retinal sensitivity. The output of VFMA and OSI is not exactly interchangeable in this cross-sectional analysis. Longitudinal analysis is necessary to assess their performance in ability-to-detect change. TRANSLATIONAL RELEVANCE: This study explores new volumetric MP endpoints for future application in therapeutic trials in iAMD and reports specific characteristics of the available HOV software applications.
Zeitschriftentitel:: Transl Vis Sci Technol
Jahr:: 2023
Band / Volume:: 12
Heft / Issue:: 8
Volltext / DOI:: doi:10.1167/tvst.12.8.21
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/37624605
TUM Einrichtung:: Institut für KI und Informatik in der Medizin (Prof. Rückert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2023