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Titel:

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Dokumenttyp:
Article; Meta-Analysis; Journal Article
Autor(en):
Buch, Stephan; Innes, Hamish; Lutz, Philipp Ludwig; Nischalke, Hans Dieter; Marquardt, Jens U; Fischer, Janett; Weiss, Karl Heinz; Rosendahl, Jonas; Marot, Astrid; Krawczyk, Marcin; Casper, Markus; Lammert, Frank; Eyer, Florian; Vogel, Arndt; Marhenke, Silke; von Felden, Johann; Sharma, Rohini; Atkinson, Stephen Rahul; McQuillin, Andrew; Nattermann, Jacob; Schafmayer, Clemens; Franke, Andre; Strassburg, Christian; Rietschel, Marcella; Altmann, Heidi; Sulk, Stefan; Thangapandi, Veera Raghavan; Br...     »
Abstract:
OBJECTIVE: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis. DESIGN: Patients with alcohol-related cirrhosis and HCC (cases: n=1214) and controls without HCC (n=1866), recruited from Ge...     »
Zeitschriftentitel:
Gut
Jahr:
2023
Band / Volume:
72
Heft / Issue:
2
Seitenangaben Beitrag:
381-391
Volltext / DOI:
doi:10.1136/gutjnl-2022-327196
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35788059
Print-ISSN:
0017-5749
TUM Einrichtung:
1298; Abteilung für Toxikologie (Prof. Eyer)
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