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Title:

Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Jarosch, Sebastian; Köhlen, Jan; Ghimire, Sakhila; Orberg, Erik Thiele; Hammel, Monika; Gaag, Doris; Evert, Matthias; Janssen, Klaus-Peter; Hiergeist, Andreas; Gessner, André; Weber, Daniela; Meedt, Elisabeth; Poeck, Hendrik; D'Ippolito, Elvira; Holler, Ernst; Busch, Dirk H
Abstract:
Acute graft-versus-host disease (aGvHD) is a significant complication after allogeneic hematopoietic stem cell transplantation (aHSCT), but major factors determining disease severity are not well defined yet. By combining multiplexed tissue imaging and single-cell RNA sequencing on gastrointestinal biopsies from aHSCT-treated individuals with fecal microbiome analysis, we link high microbiome diversity and the abundance of short-chain fatty acid-producing bacteria to the sustenance of suppressiv...     »
Journal title abbreviation:
Cell Rep Med
Year:
2023
Journal volume:
4
Journal issue:
7
Fulltext / DOI:
doi:10.1016/j.xcrm.2023.101125
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37467715
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch); Klinik und Poliklinik für Chirurgie (Prof. Friess); Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann)
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