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Title:

Serial Analysis of Gene Mutations and Gene Expression during First-Line Chemotherapy against Metastatic Colorectal Cancer: Identification of Potentially Actionable Targets within the Multicenter Prospective Biomarker Study REVEAL.

Document type:
Article; Journal Article
Author(s):
Kumbrink, Jörg; Bohlmann, Lisa; Mamlouk, Soulafa; Redmer, Torben; Peilstöcker, Daniela; Li, Pan; Lorenzen, Sylvie; Algül, Hana; Kasper, Stefan; Hempel, Dirk; Kaiser, Florian; Michl, Marlies; Bartsch, Harald; Neumann, Jens; Klauschen, Frederick; von Bergwelt-Baildon, Michael; Modest, Dominik Paul; Stahler, Arndt; Stintzing, Sebastian; Jung, Andreas; Kirchner, Thomas; Schäfer, Reinhold; Heinemann, Volker; Holch, Julian W
Abstract:
Most metastatic colorectal cancer (mCRC) patients succumb to refractory disease due to secondary chemotherapy resistance. To elucidate the molecular changes associated with secondary resistance, we recruited 64 patients with mCRC and hepatic metastases before standard first-line chemotherapy between 2014 and 2018. We subjected DNA from primary tumor specimens (P), hepatic metastasis specimens after treatment (M), and liquid biopsies (L) taken prior to (pre), during (intra), and after (post) trea...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2022
Journal volume:
14
Journal issue:
15
Fulltext / DOI:
doi:10.3390/cancers14153631
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35892888
TUM Institution:
608; Lehrstuhl für Tumormetabolismus (Prof. Algül)
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