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Title:

Lower cortical thickness and increased brain aging in adults with cocaine use disorder.

Document type:
Journal Article
Author(s):
Schinz, David; Schmitz-Koep, Benita; Tahedl, Marlene; Teckenberg, Timo; Schultz, Vivian; Schulz, Julia; Zimmer, Claus; Sorg, Christian; Gaser, Christian; Hedderich, Dennis M
Abstract:
BACKGROUND: Cocaine use disorder (CUD) is a global health issue with severe behavioral and cognitive sequelae. While previous evidence suggests a variety of structural and age-related brain changes in CUD, the impact on both, cortical thickness and brain age measures remains unclear. METHODS: Derived from a publicly available data set (SUDMEX_CONN), 74 CUD patients and 62 matched healthy controls underwent brain MRI and behavioral-clinical assessment. We determined cortical thickness by surface-based morphometry using CAT12 and Brain Age Gap Estimate (BrainAGE) via relevance vector regression. Associations between structural brain changes and behavioral-clinical variables of patients with CUD were investigated by correlation analyses. RESULTS: We found significantly lower cortical thickness in bilateral prefrontal cortices, posterior cingulate cortices, and the temporoparietal junction and significantly increased BrainAGE in patients with CUD [mean (SD) = 1.97 (±3.53)] compared to healthy controls (p < 0.001, Cohen's d = 0.58). Increased BrainAGE was associated with longer cocaine abuse duration. CONCLUSION: Results demonstrate structural brain abnormalities in CUD, particularly lower cortical thickness in association cortices and dose-dependent, increased brain age.
Journal title abbreviation:
Front Psychiatry
Year:
2023
Journal volume:
14
Fulltext / DOI:
doi:10.3389/fpsyt.2023.1266770
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38025412
TUM Institution:
Professur für Neuroradiologie (Prof. Zimmer)
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