Adherence to a risk-adapted screening strategy for prostate cancer: First results of the PROBASE trial.

Krilaviciute, Agne; Albers, Peter; Lakes, Jale; Radtke, Jan Philipp; Herkommer, Kathleen; Gschwend, Jürgen; Peters, Inga; Kuczyk, Markus; Koerber, Stefan A; Debus, Jürgen; Kristiansen, Glen; Schimmöller, Lars; Antoch, Gerald; Makowski, Marcus; Wacker, Frank; Schlemmer, Heinz; Benner, Axel; Giesel, Frederik; Siener, Roswitha; Arsov, Christian; Hadaschik, Boris; Becker, Nikolaus; Kaaks, Rudolf

doi:10.1002/ijc.34295

journal article

Title:: Adherence to a risk-adapted screening strategy for prostate cancer: First results of the PROBASE trial.
Document type:: Journal Article
Author(s):: Krilaviciute, Agne; Albers, Peter; Lakes, Jale; Radtke, Jan Philipp; Herkommer, Kathleen; Gschwend, Jürgen; Peters, Inga; Kuczyk, Markus; Koerber, Stefan A; Debus, Jürgen; Kristiansen, Glen; Schimmöller, Lars; Antoch, Gerald; Makowski, Marcus; Wacker, Frank; Schlemmer, Heinz; Benner, Axel; Giesel, Frederik; Siener, Roswitha; Arsov, Christian; Hadaschik, Boris; Becker, Nikolaus; Kaaks, Rudolf
Abstract:: PROBASE is a population-based, randomized trial of 46 495 German men recruited at age 45 to compare effects of risk-adapted prostate cancer (PCa) screening starting either immediately at age 45, or at a deferred age of 50 years. Based on prostate-specific antigen (PSA) levels, men are classified into risk groups with different screening intervals: low-risk (<1.5 ng/ml, 5-yearly screening), intermediate-risk (1.5-2.99 ng/ml, 2 yearly), and high risk (>3 ng/ml, recommendation for immediate biopsy). Over the first 6 years of study participation, attendance rates to scheduled screening visits varied from 70.5% to 79.4%, depending on the study arm and risk group allocation, in addition 11.2% to 25.4% of men reported self-initiated PSA tests outside the PROBASE protocol. 38.5% of participants had a history of digital rectal examination or PSA testing prior to recruitment to PROBASE, frequently associated with family history of PCa. These men showed higher rates (33% to 57%, depending on subgroups) of self-initiated PSA testing in-between PROBASE screening rounds. In the high-risk groups (both arms), the biopsy acceptance rate was 64% overall, but was higher among men with screening PSA ≥4 ng/ml (>71%) and with PIRADS ≥3 findings upon multiparameter magnetic resonance imaging (mpMRI) (>72%), compared with men with PSA ≥3 to 4 ng/ml (57%) or PIRADS score ≤ 2 (59%). Overall, PROBASE shows good acceptance of a risk-adapted PCa screening strategy in Germany. Implementation of such a strategy should be accompanied by a well-structured communication, to explain not only the benefits but also the harms of PSA screening.
Journal title abbreviation:: Int J Cancer
Year:: 2023
Journal volume:: 152
Journal issue:: 5
Pages contribution:: 854-864
Fulltext / DOI:: doi:10.1002/ijc.34295
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/36121664
Print-ISSN:: 0020-7136
TUM Institution:: 1145; Institut für Diagnostische und Interventionelle Radiologie ; Klinik und Poliklinik für Urologie
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