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Title:

The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zilli, Federica; Marques Ramos, Pedro; Auf der Maur, Priska; Jehanno, Charly; Sethi, Atul; Coissieux, Marie-May; Eichlisberger, Tobias; Sauteur, Loïc; Rouchon, Adelin; Bonapace, Laura; Pinto Couto, Joana; Rad, Roland; Jensen, Michael Rugaard; Banfi, Andrea; Stadler, Michael B; Bentires-Alj, Mohamed
Abstract:
Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programmes are known to regulate the metastatic cascade but the molecular determinants of metastatic colonization remain elusive. Using an inducible piggyBac (PB) transposon mutagenesis screen, we have shown that overexpression of the transcription factor nuclear factor IB (NFIB) alone is sufficient to enhance primary mammary tumour growth and lung metastatic colonization. Mechanistically and functionally, NF...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2021
Journal volume:
13
Journal issue:
4
Fulltext / DOI:
doi:10.15252/emmm.202013162
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33751828
Print-ISSN:
1757-4676
TUM Institution:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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