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Title:

MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress.

Document type:
Journal Article
Author(s):
Sipol, Alexandra; Hameister, Erik; Xue, Busheng; Hofstetter, Julia; Barenboim, Maxim; Öllinger, Rupert; Jain, Gaurav; Prexler, Carolin; Rubio, Rebeca Alba; Baldauf, Michaela Carina; Franchina, Davide G; Petry, Andreas; Schmäh, Juliane; Thiel, Uwe; Gorlach, Agnes; Cario, Gunnar; Brenner, Dirk; Richter, Günther; Grünewald, Thomas G P; Rad, Roland; Wolf, Elmar; Ruland, Jürgen; Sorensen, Poul H; Burdach, Stefan E G
Abstract:
Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced metabolic stress through intrinsic or acquired antimetabolic stress responses to maintain homeostasis and survival. One mechanism to achieve this is reprogramming gene expression in a metabolism-dependent manner. MondoA (also known as Myc-associated factor X-like protein X-interacting protein [MLXIP]), a member of the MYC interactome, has been de...     »
Journal title abbreviation:
Blood
Year:
2022
Journal volume:
139
Journal issue:
8
Pages contribution:
1184-1197
Fulltext / DOI:
doi:10.1182/blood.2020007932
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33908607
Print-ISSN:
0006-4971
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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