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Titel:

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.

Dokumenttyp:
Meeting Abstract; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Dudek, Michael; Pfister, Dominik; Donakonda, Sainitin; Filpe, Pamela; Schneider, Annika; Laschinger, Melanie; Hartmann, Daniel; Hüser, Norbert; Meiser, Philippa; Bayerl, Felix; Inverso, Donato; Wigger, Jennifer; Sebode, Marcial; Öllinger, Rupert; Rad, Roland; Hegenbarth, Silke; Anton, Martina; Guillot, Adrien; Bowman, Andrew; Heide, Danijela; Müller, Florian; Ramadori, Pierluigi; Leone, Valentina; Garcia-Caceres, Cristina; Gruber, Tim; Seifert, Gabriel; Kabat, Agnieszka M; Mallm, Jan-Philipp; Re...     »
Abstract:
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liver disease and cancer1,2. The accumulation of metabolites leads to cell stress and inflammation in the liver3, but mechanistic understandings of liver damage in NASH are incomplete. Here, using a preclinical mouse model that displays key features of human NASH (hereafter, NASH mice), we found an indispensable role for T cells in liver immunopathology. We detected the hepatic acc...     »
Zeitschriftentitel:
Nature
Jahr:
2021
Band / Volume:
592
Heft / Issue:
7854
Seitenangaben Beitrag:
444-449
Volltext / DOI:
doi:10.1038/s41586-021-03233-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33762736
Print-ISSN:
0028-0836
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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