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Title:

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Breunig, Markus; Merkle, Jessica; Wagner, Martin; Melzer, Michael K; Barth, Thomas F E; Engleitner, Thomas; Krumm, Johannes; Wiedenmann, Sandra; Cohrs, Christian M; Perkhofer, Lukas; Jain, Gaurav; Krüger, Jana; Hermann, Patrick C; Schmid, Maximilian; Madácsy, Tamara; Varga, Árpád; Griger, Joscha; Azoitei, Ninel; Müller, Martin; Wessely, Oliver; Robey, Pamela G; Heller, Sandra; Dantes, Zahra; Reichert, Maximilian; Günes, Cagatay; Bolenz, Christian; Kuhn, Florian; Maléth, József; Speier, Stephan;...     »
Abstract:
Personalized in vitro models for dysplasia and carcinogenesis in the pancreas have been constrained by insufficient differentiation of human pluripotent stem cells (hPSCs) into the exocrine pancreatic lineage. Here, we differentiate hPSCs into pancreatic duct-like organoids (PDLOs) with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon transplantation into mice. PDLOs are generated from hPSCs inducibly expressing oncogenic...     »
Journal title abbreviation:
Cell Stem Cell
Year:
2021
Journal volume:
28
Journal issue:
6
Pages contribution:
1105-1124.e19
Fulltext / DOI:
doi:10.1016/j.stem.2021.03.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33915078
Print-ISSN:
1934-5909
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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