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Title:

SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Pacharne, Suruchi; Dovey, Oliver M; Cooper, Jonathan L; Gu, Muxin; Friedrich, Mathias J; Rajan, Sandeep S; Barenboim, Maxim; Collord, Grace; Vijayabaskar, M S; Ponstingl, Hannes; De Braekeleer, Etienne; Bautista, Ruben; Mazan, Milena; Rad, Roland; Tzelepis, Konstantinos; Wright, Penny; Gozdecka, Malgorzata; Vassiliou, George S
Abstract:
Advances in cancer genomics have revealed genomic classes of acute myeloid leukemia (AML) characterized by class-defining mutations, such as chimeric fusion genes or in genes such as NPM1, MLL, and CEBPA. These class-defining mutations frequently synergize with internal tandem duplications in FLT3 (FLT3-ITDs) to drive leukemogenesis. However, ∼20% of FLT3-ITD-positive AMLs bare no class-defining mutations, and mechanisms of leukemic transformation in these cases are unknown. To identify pathways...     »
Journal title abbreviation:
Blood Adv
Year:
2021
Journal volume:
5
Journal issue:
9
Pages contribution:
2412-2425
Fulltext / DOI:
doi:10.1182/bloodadvances.2020003443
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33956058
Print-ISSN:
2473-9529
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Klinik und Poliklinik für Kinder- und Jugendmedizin; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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